News

Research solutions for COVID-19

BioNordika can supply several products in order to detect SARS-CoV-2:

• Primer and probes
• Library prep kits
• Amplification and detection products
• Kits for purification of RNA
• Spectrophotometer for quantification of RNA and DNA
• qPCR kits
• Detection assays
• SARS CoV-2 specific antibodies
• Kit for rapid detection SARS CoV-2

Research solutions for COVID-19

Corona viruses are a family of viruses that includes the common cold and more severe diseases as MERS and SARS. In December 2019 a new corona virus first called 2019-nCoV (2019 novel Coronavirus, now called SARS-CoV-2) was discovered in the city of Wuhan in China. The virus causes the disease called COVID-19, which can give a respiratory illness of mild or severe degree. The illness is though to spread via respiratory droplets produced when an infected person sneezes or coughs.

The outbreak of COVID-19 was declared by WHO as a pandemic on the 11th of March 2020. Scientists throughout the world are encouraged to help developing a treatment.

SARS-CoV-2 binds to ACE2 receptors that can be found on the surface of a range of human cells, in vascular endothelium, heart, kidney and alveolar epithelial cells in the lungs (Nature, 2020). This is the same entry point as SARS-CoV uses to enter cells. The reseptor is mainly expressed on cells in the lower respiratory tracts.

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Radleys Catalog 2020

Check out the new catalog from Radleys with their high quality equipment for chemical synthesis, process development, evaporation and work-up. 

Download the catalog

Radleys Catalog 2020

eCHO Medium

Maximize your protein production

eCHO medium from Lonza is designed to maximize protein integrity, positively affected by low levels of lactate and late-stage viability. With over 40 years of expertise in media development, Lonza is proud to introduce eCHO Basal Medium and Feed. The serum-free, chemically defined, hydrolysate-free and non-animal origin (NAO) eCHO Medium optimizes your cell proliferation and protein production.

eCHO Medium

Improved productivity:
Consistent titer levels of 3.0 g/L using a qualified clone within 14 culture days in a fed batch culture.

Ease of use:
One part liquid and one part feed in both powder and liquid formats

Consistency:
Liquid products produced from (one) powder.

Product Quality:
High viability to end of cell culture in addition to low lactate levels, securing protein integrity and posttranslational modification.

Learn more

Nexera UHPLC Series from Shimadzu

Intelligence and efficiency
Shimadzu Corporation announces the release of the Nexera Ultra High-Performance Liquid Chromatograph series, incorporating artificial intelligence as Analytical Intelligence, allowing systems to detect and resolve issues automatically. The Nexera series makes lab management simple by integrating IoT and device networking, enabling users to easily review instrument status, optimize resource allocation, and achieve higher throughput.

The Nexera UHPLC series maximizes reliability and uptime with fully unattended workflows that span from startup to shut-down. Operators can set the Nexera to start up at a specified time, so that it can complete auto-purge, equilibration, baseline checks and system suitability in advance, and be ready for analysis before they arrive at the lab. In addition, FlowPilot ramps up the flow rate gradually, reducing the possibility of damage to columns. The Nexera also has auto-diagnostics and auto-recovery capabilities that allow it to monitor pressure fluctuations to check for anomalies.

With remote mobile phase monitoring and integrated consumables management, the system maximizes uptime and reliability. Real-time monitoring of mobile phase levels allows lab personnel to efficiently run batches and respond accordingly if there isn’t enough mobile phase before starting a run. In addition, Nexera tracks consumable usage and sends alerts when parts need replacing, allowing users to keep the system running at peak performance. The Nexera UHPLC series allows analysts to confirm parameters and monitor chromatograms in real time directly from a web browser on their smart device.

Design
The Nexera’s elegant, compact design saves valuable bench space. Because it uses over 80% less electricity when on standby, it significantly reduces running costs and supports an environmentally-friendly lab.

Nexera UHPLC brochure

Nexera UHPLC Series from Shimadzu
Nexera UHPLC Series from Shimadzu

Ferroptose - a new form of cell death

Ferroptosis was recently identified as a form of programmed cell death. Activation of ferroptosis results in destruction of certain cancer cells, whereas inhibition of this process may protect organisms from neurodegeneration

CaymanCurrents no.4, 2018 is focused on ferroptosis and there you will find amongst other:  
• The Ferroptosis Pathway: Structure, Function, and Modulation
• Ferroptosis Inducers
• Ferroptosis Inhibitors

Download the pdf here.

Ferroptose - a new form of cell death

LC/MS from Shimadzu

LCMS-9030 Q-TOF

The LCMS-9030 (picture) uses newly patented technologies to deliver both high resolution and accurate mass, attributes essential for confident formula assignment and unknown identification.

• Greater accuracy
• Better sensitivity
• Higher resolution

Download the brochure for LCMS-9030.

Shimadzu Mikros

The Nexera Mikros can be used to detect target components with higher sensitivity than with semi-micro flowrate compatible LCMS systems, which perform measurements within a flowrate range of 100 μL/min to 500 μL/min.

Nexera Mikros improves operability, and at the same time, enables high-sensitivity analysis with smaller system capacity. This is due to the UF-Link, which enables one-touch connection and disconnection between the LCMS ionization interface and the analytical columns.

Download the brochure for Nexera Mikros.

LC/MS from Shimadzu

New VECTASTAIN® ABC and ImmPRESS® Polymer IHC kits

We are pleased to introduce the VECTASTAIN® Elite® ABC Universal PLUS Kit (#PK-8200) and three new ImmPRESS® Universal PLUS Polymer Kit (#MP-7800, #MP-7801 og #MP-7802) from Vector Laboratories.

These new peroxidase (HRP) IHC kits contain matching volume reagents, provided as prediluted, ready-to-use formats, and importantly, also include our endogenous enzyme quenching solution BLOXALL® (SP-6000) and the ImmPACT® DAB EqV peroxidase substrate (SK-4103).

These “PLUS” kits are suitable for both manual and automated IHC staining applications, and they are intended to provide a more streamlined and convenient workflow.

New VECTASTAIN® ABC and ImmPRESS® Polymer IHC kits

Black or white coffee we know, but what makes the lids black or white?

Disposable plastic is a hot topic. Here Shimadzu has analyzed a product designed to contain heat – Coffee cup lids. Both lids display the symbol of recyclable Poly Styrene but have different colors. The question is what makes one appear white and the other black? Analysis by the non-destructive techniques FTIR and EDX can answer that.
Read the application summary

Black or white coffee we know, but what makes the lids black or white?

NEBNext® Single Cell/Low Input RNA Library Prep Kit for Illumina®

NEBNext® is now available for single cell and ultra-low RNA inputs!

NEBNext® Single Cell/Low Input RNA Library Prep Kit for Illumina®
This unique workflow meets the demand for a highly sensitive, yet robust method that consistently enables generation of high quality sequencing data from single cell or ultra-low input RNA.

• Generate the highest yields of high-quality sequencing libraries from single cells, or as little as 2 pg - 200 ng RNA
• Experience unmatched detection of low abundance transcripts
• Rely on consistent transcript detection for a wide range of input amounts and sample types
• Observe uniform transcript coverage, regardless of input amount or sample type
• Use with a variety of RNA inputs, including cultured or primary cells, or total RNA
• Save time with a fast, streamlined workflow, minimal handling steps and hands-on time

Technical note

NEBNext® Single Cell/Low Input RNA Library Prep Kit for Illumina®

Monarch Total RNA MiniPrep kit

The new Monarch Total RNA Miniprep Kit from NEB is optimized for use with a wide variety of sample types, including cells, tissue, blood and more, so that one convenient kit can serve your RNA purification needs.

Learn more about the nucleic acid purification kits from NEB here.

Monarch Total RNA MiniPrep kit