Endotoxin Detection Assays
Endotoxins, a type of pyrogen, are natural
compounds found in the outer cell membrane of Gram-negative bacteria and impacts
over 30 biological activities. Endotoxin can lead to cell death by initiating
The Limulus Amebocyte Lysate (LAL) test was
commercially introduced in the 1970s. LAL is derived from the blood cells, or
amebocytes, of the horseshoe crab, Limulus polyphemus. Frederick Bang
and Jack Levin observed that blood cells from horseshoe crabs were found to clot
in the presence of endotoxin, and this technology was used in the development of
endotoxin detection assays.
Today, endotoxin tests are performed on raw and
in-process materials, and for the final release of products in the
pharmaceutical and medical device industries.
Using extensive experience with endotoxin
detection and its regulatory requirements, Lonza has been able to deliver
innovative and time-saving tools for both the pharmaceutical and research
Their offerings include:
- PYROGENT™ Gel Clot LAL Assays
- PYROGENT™ – 5000 Kinetic Turbidimetric LAL Assays
- QCL-1000™ Endpoint Chromogenic LAL Assays
- Kinetic-QCL™ Kinetic Chromogenic LAL Assays
- PyroGene™ rFC Endpoint Chromogenic Fluorescent Assay
For detailed product information, contact us, or click here.