Endotoxins, a type of pyrogen, are natural compounds found in the outer cell membrane of Gram-negative bacteria and impacts over 30 biological activities. Endotoxin can lead to cell death by initiating complement activation.
The Limulus Amebocyte Lysate (LAL) test was commercially introduced in the 1970s. LAL is derived from the blood cells, or amebocytes, of the horseshoe crab, Limulus polyphemus. Frederick Bang and Jack Levin observed that blood cells from horseshoe crabs were found to clot in the presence of endotoxin, and this technology was used in the development of endotoxin detection assays.
Today, endotoxin tests are performed on raw and in-process materials, and for the final release of products in the pharmaceutical and medical device industries.
Using extensive experience with endotoxin detection and its regulatory requirements, Lonza has been able to deliver innovative and time-saving tools for both the pharmaceutical and research markets.
Their offerings include:
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